何治宇 / He Zhiyu | ||||||
职 称： | 教授 |
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办公电话： | 无 | |||||
个人邮箱： | hezhiyu@ouc.edu.cn | |||||
地 址： | 崂山校区海化楼203室 | |||||
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个人主页： | ||||||
研究领域或方向： | ||||||
1. 新型生物可降解、生物安全的功能性高分子聚合物的精密合成及应用； 2. 蛋白/核酸类生物大分子创新口服递送材料和载体的开发与应用； 3. 构建具有多功能、高载药、靶向、缓/控释、环境响应型纳米药物输送载体，重点在抗菌、糖尿病、急性重症疾病、心血管疾病、肿瘤等的应用。 | ||||||
工作经历： |
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2020.03-至今，中国海洋大学教授 2017.06-2020.01 美国约翰霍普金斯大学博士后研究员 | ||||||
主持或参与的项目： |
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主持和参与国家自然科学基金4项 | ||||||
学术成果： |
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2023 1.Rapidly inhibiting the inflammatory cytokine storms and restoring cellular homeostasis to alleviate sepsis by blocking pyroptosis and mitochondrial apoptosis pathways.Jiahui Yan, Jingwen Zhang, Yanan Wang, Hong Liu, Xueping Sun, Aixin Li, Liangmin Yu*, Xuefeng Yan, Zhiyu He*.Advanced Science, (2023）2207448，通讯作者，IF：17.521，JCR 1区&中科院1区TOP期刊 2.Rapidly Blocking the Calcium Overload/ROS Production Feedback Loop to Alleviate Acute Kidney Injury via Microenvironment-Responsive BAPTA-AM/BAC Co-Delivery Nanosystem. Jiahui Yan, Yanan Wang, Jingwen Zhang, Xiaohu Liu, Liangmin Yu, Zhiyu He*.Small, (2023）202206936, 通讯作者，IF：15.153，JCR 1区&中科院1区TOP期刊 3.1,2-Bis(2-aminophenoxy)ethane‐N,N,N′,N′‐tetraacetic Acid Acetoxymethyl Ester Loaded Reactive Oxygen Species Responsive Hyaluronic Acid-Bilirubin Nanoparticles for Acute Kidney Injury Therapy via Alleviating Calcium Overload Mediated Endoplasmic Reticulum Stress. Yanan Wang, Minju Pu, Jiahui Yan, Jingwen Zhang, Huichao Wei, Liangmin Yu,* Xuefeng Yan, Zhiyu He*.ACS Nano, 17 (2023）472-491 通讯作者，IF：18.027，JCR 1区&中科院1区TOP期刊 2022 4.The Advancement of Gas-Generating Nanoplatforms in Biomedical Fields: Current Frontiers and Future Perspectives. Jiahui Yan, Yanan Wang, Xinyu Song, Xuefeng Yan, Yi Zhao*, Liangmin Yu, Zhiyu He*.Small Methods, (2022) 2200139. 通讯作者，IF：15.367，JCR 1区&中科院1区TOP期刊 5.Innovations and challenges of polyphenol-based smart drug delivery systems. Yanan Wang#, Jingwen Zhang#, Yi Zhao, Minju Pu, Xinyu Song, Liangmin Yu*, Xuefeng Yan, Jun Wu*, Zhiyu He*. Nano Research.(2022)通讯作者，IF: 10.269，JCR 1区&中科院1区TOP期刊 6. Cell-Selective Encapsulation within Metal–Organic Framework Shells via Precursor-Functionalized Aptamer Identification for Whole-Cell Cancer Vaccine. Huihui Yang, Yanfei Zhang, Leli Zeng, Wen Yin, Yuzhi Xu*, Jun Chen, Siyang Liu*, Xiaoyong Zou, Zhiyu He, Zong Dai*. Small Methods,（2022）2101391. 共同作者，IF：15.367，JCR 1区&中科院1区TOP期刊 2021 7.Kinetic control of Phytic acid/Lixisenatide/Fe (III) ternary nanoparticles assembly process for sustained peptide release. Yanan Wang#, Xinyu Song#, Liwei Zhuang#, Haifeng Lang, Liangmin Yu*, Xuefeng Yan, Zhiyu He*. International Journal of Pharmaceutics, 611 (2021) 121317. 通讯作者，IF: 6.51，JCR 1区&中科院2区 TOP期刊 8.Dealing with MDR bacteria and biofilm in the post-antibiotic era: application of antimicrobial peptides-based nano-formulation. Xinyu Song#, Pengyan Liu#, Xiaohu Liu, Yanan Wang, Huichao Wei, Jingwen Zhang, Liangmin Yu*, Xuefeng Yan, Zhiyu He*. Materials Science and Engineering: C,128 (2021) 112318. 通讯作者，IF: 8.457，JCR 1区&中科院1区TOP期刊 9.Application of nanotechnology in acute kidney injury: From diagnosis to therapeutic implications. Yi Zhao#, Minju Pu#, Yanan Wang, Liangmin Yu*, Xinyu Song and Zhiyu He*. Journal of Controlled Release,336 (2021) 233-251.通讯作者，IF: 11.467，JCR 1区&中科院1区TOP期刊 10.Recent advancements of nanomaterial-based therapeuti strategies toward sepsis: bacterial eradication, anti-inflammation and immunomodulation. Yi Zhao#, Minju Pu#, Jingwen Zhang, Yanan Wang, Xuefeng Yan, Liangmin Yu* and Zhiyu He*. Nanoscale, 13 (2021) 10726-10747. 通讯作者，IF: 8.307，JCR 1区&中科院1区TOP期刊 11.Sustained Release Systems for Delivery of Therapeutic Peptide/Protein. Tianqi Nie#, Wei Wang#, Xiaohu Liu#, Yanan Wang, Keyang Li, Xinyu Song, Jingwen Zhang, Liangmin Yu*, Zhiyu He*. Biomacromolecules 22, no. 6 (2021) 2299-2324. 通讯作者，IF: 6.998，JCR 1区&中科院1区TOP期刊 12.Nanomaterial-based stategies in antimicrobial application：Progress and Perspectives. Yi Zhao#, Long Chen#, Yanan Wang#, Xinyu Song, Xuefeng Yan, Liangmin Yu*, and Zhiyu He*. Nano Research.(2021)通讯作者，IF: 10.269，JCR 1区&中科院1区TOP期刊 13.Recent advances of nanomedicine-based strategies in diabetes and complications management: Diagnostics, monitoring, and therapeutics. Yanan Wang, Chunhui Wang, Keyang Li, Xinyu Song, Xuefeng Yan, Liangmin Yu*, and Zhiyu He*.Journal of Controlled Release 330 (2021) 618-640.通讯作者，IF: 11.467，JCR 1区&中科院1区 TOP期刊 14.Non-invasive delivery of levodopa-loaded nanoparticles to the brain via lymphatic vasculature to enhance treatment of Parkinson’s disease. Tianqi Nie#, Zhiyu He#*, Jinchang Zhu, Kuntao Chen, Gregory P Howard, II Minn, Pengfei Zhao, Zaver M Bhujwalla, Hai-Quan Mao, Lixin Liu and Yongming Chen*. Nano Research 14 (2021)2749-2761共同第一作者&通讯作者 IF: 10.269，JCR 1区&中科院1区TOP期刊 2020 15.A Review on Antimicrobial Coatings for Biomaterial Implants and Medical Devices. Long Chen#, Xinyu Song#, Fei Xing#, Yanan Wang, Yuanzheng Wang, Zhiyu He*, and Li Sun*. Journal of Biomedical Nanotechnology 16, no. 6 (2020) 789-809. 通讯作者，IF: 4.48，JCR 1区&中科院2区 16.Prolonged melittin release from polyelectrolyte-based nanocomplexes decreases acute toxicity and improves blood glycemic control in a mouse model of type II diabetes. Zaizhi Gui, Jinchang Zhu, Song Ye, Jiao Chen, Yuanyuan Ling, Xueting Cai, Peng Cao, Zhiyu He*, and Chunping Hu*. International Journal of Pharmaceutics 577 (2020) 119071. 通讯作者，IF: 6.51，JCR 1区&中科院2区 TOP期刊 17.One-Pot Synthesis of PEGylated Lipoplexes to Facilitate Mucosal Permeation for Oral Insulin Gene Delivery. Tianqi Nie#, Zhiyu He*, Jinchang Zhu, Lixin Liu, and Yongming Chen*. Advanced Therapeutics 3, no. 3 (2020) 2000016. 共同第一作者&通讯作者，IF: 5.003 18.A polyphenol-metal nanoparticle platform for tunable release of liraglutide to improve blood glycemic control and reduce cardiovascular complications in a mouse model of type II diabetes. Zhiyu He*, Tianqi Nie, Yizong Hu, Jinchang Zhu, Lixin Liu, Kam W. Leong, Yongming Chen*, and Hai-Quan Mao*. Journal of Controlled Release, 318 (2020) 86-97. 第一作者&通讯作者，IF: 11.467，JCR 1区&中科院1区TOP期刊 19.A microfluidics-derived growth factor gradient in a scaffold regulates stem cell activities for tendon-to-bone interface healing. Lyu, Jingtong, Long Chen, Jiqiang Zhang, Xia Kang, Wenjie Wu, Hong Tang, Jun Wu*, Zhiyu He*, and Kanglai Tang*. Biomaterials Science 8(2020) 3649-3663. 共同通讯作者，IF: 7.59，JCR 1区&中科院2区TOP期刊 20.Tailor-made legumain/pH dual-responsive doxorubicin prodrug-embedded nanoparticles for efficient anticancer drug delivery and in situ monitoring of drug release. Li, Yang, Yimin Niu, Jianhua Zhu, Cuicui Gao, Qunwei Xu, Zhiyu He, Dawei Chen, Ming Xu, and Yang Liu. Nanoscale 12, no. 4 (2020) 2673-2685. IF: 8.307，JCR 1区&中科院1区TOP期刊 21.Programmed co-delivery of platinum nanodrugs and gemcitabine by a clustered nanocarrier for precision chemotherapy for NSCLC tumors. Huihui Shi, Ming Xu, Jianhua Zhu, Yang Li, Zhiyu He, Yuxia Zhang, Qunwei Xu, Yimin Niu, and Yang Liu. Journal of Materials Chemistry B 8, no. 2 (2020) 332-342. IF: 7.571，JCR 1区&中科院2区 2019 22.Elimination of Intracellular Calcium Overload by BAPTA-AM-Loaded Liposomes: A Promising Therapeutic Agent for Acute Liver Failure. Zailin Fu, Qiaomei Fan, Yang Zhou, Yi Zhao*, and Zhiyu He*. ACS Applied Materials & Interfaces 11, no. 43 (2019) 39574-39585. 通讯作者，IF:10.383，JCR 1区&中科院1区TOP期刊 23.Kinetic control in assembly of plasmid DNA/polycation complex nanoparticles. Yizong Hu, Zhiyu He, Yue Hao, Like Gong, Marion Pang, Gregory P. Howard, Hye-Hyun Ahn. ACS Nano 13, no. 9 (2019): 10161-10178.IF: 18.027，JCR 1区&中科院1区TOP期刊 24.Surface Coating Approach to Overcome Mucosal Entrapment of DNA Nanoparticles for Oral Gene Delivery ofGlucagon-like Peptide 1. Tianqi Nie#, Zhiyu He#*, Yang Zhou, Jinchang Zhu, Lixin Liu, Kam W. Leong, Hai-Quan Mao, and Yongming Chen*. ACS Applied Materials & Interfaces, 11, no. 33 (2019) 29593-29603. 共同第一作者&通讯作者，IF: 10.383，JCR 1区&中科院1区TOP期刊 25.Sustained release of exendin-4 from tannic acid/Fe (III) nanoparticles prolongs blood glycemic control in a mouse model of type II diabetes. Zhiyu He, Yizong Hu, Zaizhi Gui, Yang Zhou, Tianqi Nie, Zhijia Liu, Peng Cao*, Yongming Chen* and Hai-Quan Mao*. Journal of Controlled Release, 301 (2019) 119-128. 第一作者，IF: 11.467，JCR 1区&中科院1区TOP期刊 26.The formation and characterization of antioxidant pickering emulsions: Effect of the interactions between gliadinand chitosan. Li, Meng-Fan, Zhi-Yu He, Guo-Yan Li, Qing-Zhu Zeng, Dong-Xiao Su, Jing-Lin Zhang, Qin Wang, Yang Yuan, and Shan He. Food Hydrocolloids 90 (2019) 482-489. IF: 11.504，JCR 1区&中科院1区TOP期刊 27.Bone marrow mesenchymal stem cells and endothelial progenitor cells co-culture enhances large segment bone defectRepair. Peng, Jing, Long Chen, Kun Peng, Xuewen Chen, Jun Wu*, Zhiyu He*, and Zhou Xiang*. Journal of biomedical nanotechnology 15, no. 4 (2019) 742-755. 共同通讯作者，IF: 4.48，JCR 1区&中科院2区 28.Three-dimensional co-culture of peripheral blood-derived mesenchymal stem cells and endothelial progenitor cells for bone regeneration. Long Chen, Jun Wu, Chengguang Wu, Fei Xing, Lang Li, Zhiyu He*, Kun Peng*, and Zhou Xiang*Journal of biomedical nanotechnology 15, no. 4 (2019) 742-755. 共同通讯作者，IF: 4.48，JCR 1区&中科院2区 2018 29.Hydrogen-bonded tannic acid-based anticancer nanoparticle for enhancement of oral chemotherapy. Le, Zhicheng, Yantao Chen, Honghua Han, Houkuan Tian, Pengfei Zhao, Chengbiao Yang, Zhiyu He et al. ACS Applied Materials & Interfaces 10, no. 49 (2018) 42186-42197. IF: 10.383，JCR 1区&中科院1区TOP期刊 30.Size-controlled lipid nanoparticle production using turbulent mixing to enhance oral DNA delivery. Zhiyu He, Yizong Hu, Tianqi Nie, Haoyu Tang, Jinchang Zhu, Kuntao Chen, Lixin Liu, Kam W. Leong*, Yongming Chen*, and Hai-Quan Mao*. Acta Biomaterialia 81 (2018) 195-207. 第一作者，IF: 10.633，JCR 1区&中科院1区 TOP期刊 31.Uniform core-shell nanoparticles with thiolated hyaluronic acid coating to enhance oral delivery of insulin. Houkuan Tian, Zhiyu He, Chengxin Sun, Chengbiao Yang, Pengfei Zhao, Lixin Liu, Kam W. Leong, Hai-Quan Mao, Zhijia Liu*, and Yongming Chen*. Advanced Healthcare Materials 7, no. 17 (2018) 1800285. IF: 11.092. JCR 1区&中科院1区TOP期刊 32.BAPTA-AM nanoparticle for the curing of acute kidney injury induced by ischemia/reperfusion. Zhiyu He, Haoyu Tang, Xinru You, Keqing Huang, Arvind Dhinakar, Yang Kang, Qiaoli Yu*, and Jun Wu*.Journal of biomedical nanotechnology 14, no. 5 (2018): 868-883. 第一作者，IF: 4.48，JCR 1区&中科院2区 33.Fine tuning of core-shell structure of hyaluronic acid/cell-penetrating peptides/siRNA nanoparticles for enhanced gene delivery to macrophages in antiatherosclerotic therapy. Zhao, Yi#, Zhiyu He#, Hai Gao, Haoyu Tang, Jianhua He, Qing Guo, Wenli Zhang, and Jianping Liu*. Biomacromolecules 19, no. 7 (2018) 2944-2956.共同第一作者，IF: 6.998，JCR 1区&中科院1区，TOP期刊 34.Significant suppression of non-small-cell lung cancer by hyfrophobic poly (ester amide) nanoparticles with highdocetaxel loading.Chen, Xing, Lili Zhao, Yang Kang, Zhiyu He, Fei Xiong, Xiang Ling, and Jun Wu*. Frontiers in Pharmacology, 9 (2018) 118. IF: 5.81，JCR 2区&中科院2区 35.Scalable production of core–shell nanoparticles by flash nanocomplexation to enhance mucosal transport for oral delivery of insulin. Zhiyu He, Zhijia Liu, Houkuan Tian, Yizong Hu, Lixin Liu, Kam W. Leong*, Hai-Quan Mao*, and Yongming Chen*. Nanoscale 10, no. 7 (2018): 3307-3319. 第一作者，IF: 8.307，JCR 1区&中科院1区 TOP期刊 2017 36.Scalable fabrication of size-controlled chitosan nanoparticles for oral delivery of insulin. Zhiyu He, Jose Luis Santos, Houkuan Tian, Huahua Huang, Yizong Hu, Lixin Liu, Kam W. Leong*, Yongming Chen*, and Hai-Quan Mao*. Biomaterials 130 (2017): 28-41. 第一作者，IF: 15.304，JCR 1区&中科院1区 TOP期刊 | ||||||
其他： |
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本课题组实验条件优越，设备齐全，组内交流机会甚多。热诚欢迎具有高分子化学、有机化学、无机化学、药学、海洋化学、生物医学等领域研究背景（具体专业方向不限）的本/硕/博士生/博士后加入本课题组！ | ||||||
