张大海
职称：副教授
学术兼职：山东省科普专家、青岛市欧美同学会建言献策委员会委员、青岛市分析测试学会副秘书长
电话（传真）：0532-66782215
Email：dahaizhang@ouc.edu.cn
教育与研究经历
1997－2001，西北工业大学高分子材料与工程专业，获学士学位
2001－2004，中国海洋大学海洋化学专业，获硕士学位
2004－2007，中国海洋大学海洋化学工程与技术专业，获博士学位
2005－2007，韩国釜庆国立大学自然科学大学博士交换项目研究员
2008－2010，日本东京大学理学院Global Center Of Excellence Researcher访问学者、研究员
2010－2011，美国俄勒冈州立大学医药学院ICBB项目研究员、博士后
2011-中国海洋大学化学化工学院教师
研究领域与兴趣
专业: 污染物生物降解、天然产物
方向:·海洋有机生物地球化学
·极端环境下微生物研究
·生物间共生关系研究
·元素的微生物循环
研究课题：
1、中国海洋大学海洋化学工程与技术教育部重点实验室资助“南海深海底泥中真菌及其生态关系研究”项目
2、中国海洋大学资助“南海深海底泥来源真菌的提取及其代谢产物研究”项目
3、教育部资助“黄河三角洲盐沼湿地互花米草内生真菌及其共生关系研究”项目
4、青岛市科委资助“壬基酚在胶州湾主要径流河口底泥来源真菌中的生物转化”
5、自然科学基金委资助“沙尘天气对近海大气中生物气溶胶粒径分布和微生物活性及群落结构的影响”子课题：沙尘气溶胶中可培养微生物及其相关性研究
6、博士后基金委资助“河口底泥来源真菌对有机环境毒素壬基酚的降解研究”项目
7、某企业合作项目“热水器水质和结垢、腐蚀相关技术研发”I期、II期
8、某企业合作项目“企业生产污水处理关键技术”I期、II期、III期、IV期
9、山东省公安厅“污水验毒系列项目”I期、II期
10、山东省地市级“污水验毒系列项目”7项
代表性成果（论文、专利、奖励）
1.Zonglin Yang, Yaqi Shi, Yan Zhang, Qingzheng Cheng, Xianguo Li*, Chunhong Zhao, Dahai Zhang*.Different pathways for 4-n-nonylphenol biodegradation by two Aspergillus strains derived from estuary sediment: Evidence from metabolites determination and key-gene identification.Journal of Hazardous Materials, 2018, 359: 203-212.
2.Yaqi Shi, Zonglin Yang, Yan Zhang, Xianguo Li, Dahai Zhang*. The Relationship Study of Biomass, Situation, and Artificial Control: the Degradation of NP Using Estuary-Derived Fungi. Water, Air, & Soil Pollution, 2018, 229: 233-242.
3.Chanjuan Li, Dahai Zhang, Jialin Peng, Xianguo Li*. The effect of pH, nitrate, iron (III) and bicarbonate on photodegradation of oxytetracycline in aqueous solution. Journal of Photochemistry and Photobiology A: Chemistry, 2018, 356: 239-247.
4.Wenchao Yang, Xianguo Li, Dahai Zhang, Lijuan Feng*. Catalytic upgrading of bio-oil in hydrothermal liquefaction of algae major model components over liquid acids. Energy Conversion and Management. 2017, 154: 336–343.
5.Ting Hao, Xiaojie Liu, James Ogg, Zhen Liang, Rong Xiang, Xiaodong Zhang, Dahai Zhang, Cai Zhang, Qiaoling Liu, Xianguo Li*. Intensified episodes of East Asian Winter Monsoon during the middle through late Holocene driven by North Atlantic cooling events: High-resolution lignin records from the South Yellow Sea, China. Earth and Planetary Science Letters, 2017, 479: 144-155.
6.Fei Gong, Ting Hao, Yue Liu, Xiaojie Liu, Dahai Zhang, Rong Xiang, Xiaodong Zhang, Qiaoling Liu, Xianguo Li*. Evidence for paleoclimate changes from lignin records of sediment core A02 in the southern Yellow Sea since ~9.5 Cal. kyr B.P. Palaeogeography, Palaeoclimatology, Palaeoecology. 2017, 479: 173-184.
7.Yanxia Lin, Wei Deng*, Shengyong Li, Jiafu Li, Guoguang Wang, Dahai Zhang, Xianguo Li*. Congener profile, distribution, sources and ecological risk of parent and alkyl-PAHs in surface sediments of Southern Yellow Sea, China. Science of the Total Environment. 2017, 580: 1309–1317.
8.韩晨, 谢绵测, 祁建华, 张文倩, 李先国, 张大海*. 青岛市不同空气质量下可培养生物气溶胶分布特征及影响因素[J]. 环境科学研究，2016, 29(9): 000-000.
9.Yan Zhang, Ying Liu, Han Dong, Xianguo Li, Dahai Zhang*. The nonylphenol biodegradation study by estuary sediment-derived fungus Penicillium simplicissimum. Environmental Science and Pollution Research, 2016, 23: 15122-15132.
10.Jiafu Li, Han Dong, Xiang Xu, Bin Han, Xianguo Li*, Chenjian Zhu, Chen Han, Shaopeng Liu, Dandan Yang, Qian Xu, Dahai Zhang*. Prediction of the bioaccumulation of PAHs in surface sediments of Bohai Sea, China and quantitative assessment of the related toxicity and health risk to humans. Marine Pollution Bulletin, 2016, 104（1-2)：92-100.
11.谢绵测，雷静，李戈辉，孔令萍，李先国，张大海*. 响应面法在海洋来源梅花状青霉LGT201107抗氧化活性物质代谢过程优化中的应用研究. 中国海洋药物，2016, 35(3): 87-92.
12.陈志香, 李先国, 张大海*. 低分子醇-盐-水相体系在草甘膦母液资源化过程中的应用研究. 现代化工，2016，36(5): 110-113.
13.Jiafu Li, Han Dong, Xianguo Li, Bin Han, Chenjian Zhu, Dahai Zhang*. Quantitatively assessing the health risk of exposure to PAHs from intake of smoked meats. Ecotoxicology and Environmental Safety, 2016, 124: 91–95.
14.Xiaoyong Duan, Yanxia Li, Xianguo Li, Yi Gao, Dahai Zhang*. Changes in terrestrial organic matters and pollutants input to the Yangtze River Estuary, East China Sea, during the past century. Envirmental Chemistry, 2016, 13, 631-640.
15.Jiafu Li, Han Dong, Dahai Zhang, Bin Han, Chenjian Zhu, Shaopeng Liu, Xiangmin Liu, Qianyao Ma, Xianguo Li. Sources and ecological risk assessment of PAHs in surface sediments from Bohai Sea and northern part of the Yellow Sea, China. Marine Pollution Bulletin, 2015, 96: 485-490.
16.董涵，马燕燕，张大海*等. 河口底泥来源真菌Trichoderma asperellum对壬基酚的降解途径, 海洋环境科学. 2015，34（6）：852-857.
17.谢绵测，李先国，张大海*. OSMAC策略及其在烟曲霉菌次级代谢产物研究中的应用，天然产物研究与开发，2015，27（9）：1668-1673。
18.韩晨，祁建华，张大海*等. 青岛近海春季沙尘天空气可培养真菌及其潜在健康风险研究, 城市环境与城市生态，2015，28（4）:18-23.
19.邓晓燕，张大海，李先国. 气相色谱法测定水体中多环芳烃的前处理方法优化. 分析试验室, 2015, 34(5): 525-528.
20.王国光，张大海,杨丹丹,彭佳琳,李先国.超声辅助碱解萃取－气相色谱－电子捕获检测器测定海洋沉积物中 8 种多溴联苯醚. 色谱，2015, 33(8): 885-891.
21.梁贞, 张大海, 王敏等. 东海泥质区中木质素的分布特征及其指示意义. 海洋环境科学. 2014, 33（4）：509-513, 530.
22.李孟芳，张大海，段晓勇等. 南黄海表层沉积物中邻苯二甲酸酯的分布特征. 海洋环境科学2014, 33（5）:682-687.
23.Xiaoyong Duan, Yanxia Li, Xianguo Li, Dahai Zhang. Alkylphenols in surface sediments of the Yellow Sea and East China Sea inner shelf: Occurrence, distribution and fate. Chemosphere, 2014, 107: 265–273.
24.Xiaoyong Duan, Yanxia Li, Xianguo Li, Dahai Zhang. Distributions and sources of polychlorinated biphenyls in the coastal East China Sea sediments. Sci. Total Environ., 2013, 463-464: 894-903.
25.Xiaoyong Duan, Yanxia Li, Xianguo Li, Dahai Zhang. Polychlorinated biphenyls in sediments of the Yellow Sea: Distribution, source identification and flux estimation. Mar. Pollut. Bull., 2013, 76(1-2): 283-290.
26.Wei Deng, Xianguo Li, Shengyong Li, Dahai Zhang. Source Apportionment of Polycyclic Aromatic Hydrocarbons in Surface Sediment of Mud Areas in the East China Sea Using Diagnostic Ratios and Factor analysis. Mar. Pollut. Bull., 2013, 70(1-2): 266-273.
27.李先国, 马燕燕，张大海. 壬基酚生物降解研究进展，中国海洋大学学报，2013，43（5）：64-69.
28.李先国，马燕燕，董涵，刘莹，张大海. 两株河口底泥来源真菌对壬基酚降解特性初探, 青岛市分析测试学会，2012年度优秀学术论文二等奖，2013.1.
29.张大海*，徐香，李先国，刘莹，董涵. 海葵内生真菌来源天然产物蛇胞菌素的构效关系解析, 青岛市分析测试学会，2012年度优秀学术论文一等奖，2013.1.
30.Dahai Zhang*, Seketsu Fukuzawa, Masayuki Satake, Xianguo Li, Takafumi kuranaga, Ai Niitsu, Kentaro Yoshizawa, and Kazuo Tachibana*. Ophiobolin O and 6-epi-ophiobolin O, Two New Cytotoxic Sesterterpenes, from Marine Derived Fungus Aspergillus sp. Nat. Prod. Comm. 2012, 7(11): 1411-1414.
31.Dahai Zhang*, Seketsu Fukuzawa, Kohtaro Sugahara, Ai Niitsu, Tomohiro Shirai, Masayuki Satake and Kazuo Tachibana*. Two new cytotoxic indole alkaloids, 2-(dimethylprop-1-ene)-costaclavine and 2-(dimethylprop-1-ene)-epicostaclavine from the marine-derived fungus Aspergillus fumigatus, J. Nat. Med. 2012, 66(1): 222-226.
32.张大海*，Edward Mitchell，刘莹，李先国， Christopher C. Thornburg，Mark Zabriskie，Kerry L. McPhail*.美国俄勒冈州外深海热液出口周边微生物研究方法初探. 第二届环渤海色谱学术报告会,2012.9, 中国青岛.
33.张大海*，Edward Mitchell，刘莹，李先国， Christopher C. Thornburg，Mark Zabriskie，Kerry L. McPhail*.美国俄勒冈州外深海热液出口周边微生物研究方法初探.山东大学学报，2012, 47（S2）:84-86.
34.Justyna Sikorska, Dahai Zhang, Christopher C. Thornburg, Edward A. Mitchell, William W. Chadwick Jr., David A. Butterfield, Mark T. Zabriskie, Jane E. Ishmael, and Kerry L. McPhail*. Cytotoxic constituents of exophiala xenobiotica, fungus isolated from deep-see hydrothermal vents. SMASH 2011, Chamonix, France.
35.Dahai Zhang*, Xianguo Li, Seketsu Fukuzawa, Masayuki Satake and Kazuo Tachibana*. Two new cytotoxic indole alkaloids, 2-(dimethylprop-1-ene)-costaclavine and 2-(dimethylprop-1-ene)-epicostaclavine from the marine-derived fungus Aspergillus fumigatus, HPLC2011, Dalian, China.
36.Dahai Zhang*, Xianguo Li, Masayuki Satake, Seketsu Fukuzawa and Kazuo Tachibana*. Ophiobolin O and 6-epi-ophiobolin O, Two New Cytotoxic Sesterterpenes, from Marine Derived Fungus Aspergillus sp. 18th NSEC, 2011, Dalian, China.
37.Dahai Zhang*, Deep-sea vent-derived microorganisms: a new source of medicinally relevant small molecule natural products for future. Guest speaker, The 7th KSMB conference, 2011, Busan, Korea.
38.Dahai Zhang, Deep-sea vent-derived microorganisms: a new source of medicinally relevant small molecule natural products. Invited speaker, The 20th Volcano conference, 2011, Seattle, USA.
39.Dahai Zhang, Christopher C. Thornburg, Edward Mitchell, T. Mark Zabriskie and Kerry L. McPhail*. Deep-sea vent-derived microorganisms, a new source of medicinally relevant small molecule natural products. 2011 Retreat of School of Pharmacy, Oregon State University, Salishan , OR, 97388, USA.
40.Dahai Zhang, Dwi Andreas Santosa, Philip J. Proteau, T. Mark Zabriskie and Taifo Mahmud*. New antibiotic drug discovery: exploration of microorganisms from unique ecosystems. 2011 Retreat of School of Pharmacy, Oregon State University, Salishan , OR, 97388, USA.
41.Viviane Nenkep, Keumja Yun, Dahai Zhang, Hong Dae Choi, Jung Sook Kang, and Byeng Wha Son*. Induced production of bromomethylchlamydosporols A and B from the marine-derived fungus Fusarium tricinctum. J. Nat. Prod. 2010, 73(12), 2061-2063.
42.Xin Han*, Chao Peng, Deshi Ye, Dahai Zhang, and Yan Lan. Dynamic bin packing with unit fraction items revisited. Information Processing Letters, 2010(110), 1049-1054.
43.Feng, Zhile, Viviane N. Nenkep, Keumja Yun, Dahai Zhang, Hong Dae Choi, Jung Sook Kang, and Byeng Wha Son*.Biotransformation of Bioactive (–)-Mellein by a Marine Isolate of Bacterium Stappia sp. J. Microbiol. Biotechnol. 2010, 20(6), 985-987.
44.Dahai Zhang, Christopher C. Thornburg, T. Mark Zabriskie and Kerry L. McPhail*. Deep-sea vent-derived microorganisms, a new source of medicinally relevant small molecule natural products. 2010 Retreat of CGRB, Oregon State University, Corvallis, OR, 97331, USA.
45.Dahai Zhang, Xiudong Yang, Jung Sook Kang, Hong Dae Choi, Byeng Wha Son. Chlorohydroaspyrones A and B, Antibacterial Aspyrone Derivatives from the Marine-Derived Fungus Exophiala sp. J. Nat. Prod. 2008, 71(8), 1458-1460.
46.Zhang Dahai, Xianguo Li, Jung Sook Kang, Hong Dae Choi,Byeng Wha Son.Redoxcitrinin, a Biogenetic Precursor of Citrinin from Marine Isolate of Fungus Penicillium sp.J. Microbiol. Biotechnol. 2007, 17(5), 865-867.
47.Dahai Zhang, Xiudong Yang, Jung Sook Kang, Hong Dae Choi, Byeng Wha Son. Circumdatin I, a New Ultraviolet-A Protecting Benzodiazepine Alkaloid from a Marine Isolate of the Fungus Exophiala.J. Antibiotics, 2008, 61(1), 40-42.
48.Dahai Zhang, Xianguo Li, Jung Sook Kang, Hong Dae Choi,Byeng Wha Son.A New α-Pyrone Derivative, 6-[(E)-Hept-1-enyl]-α-pyrone, with Tyrosinase Inhibitory Activity from a Marine Isolate of the Fungus Botrytis.Bull. Korean Chem. Soc. 2007, 28(5), 887-888.
49.Hung Phi Nguyen,Dahai Zhang, Uk Lee,Jung Sook Kang, Hong Dae Choi,Byeng Wha Son.Dehydroxychlorofusarielin B, an Antibacterial Polyoxygenated Decalin Derivative from the Marine-Derived Fungus Aspergillus sp. J.Nat. Prod. 2007, 70(7), 1188-1190.
50.Xifeng Li, Dahai Zhang, Uk Lee, Xianguo Li, Jiagao Cheng, Weiliang Zhu, Jee H. Jung, Hong Dae Choi,Byeng Wha Son.Bromomyrothenone B and Botrytinone, Cyclopentenone Derivatives from a Marine Isolate of the Fungus Botrytis. J. Nat. Prod. 2007, 70, 307-309.
51.Chuanhui Gao, Xianguo Li, Lijuan Feng, Zhanchang Xiang, Dahai Zhang. Preparation and thermal decomposition of 5Mg(OH)2MgSO42H2O nanowaskers. Chemical Engineering Journal, 2009, 150, 551-554.
52.Feng, Zhile, Viviane N. Nenkep, Keumja Yun, Dahai Zhang, Hong Dae Choi, Jung Sook Kang, and Byeng Wha Son.Biotransformation of Bioactive (–)-Mellein by a Marine Isolate of Bacterium Stappia sp. J. Microbiol. Biotechnol. 2010, 20(6), 985-987.
53.Dahai Zhang, Dedi Noviendri, Muhammad Nursid, Xiudong Yang, Byeng Wha Son. Korean Soc. 12,13-Dihydroxyfumitremorgin C, Fumitremorgin C, and Brevianamide F, Antibacterial Diketopiperazine Alkaloids from the Marine-Derived Fungus Pseudallescheria sp. Natural Product Sciences, 2007, 13(3), 251-254.
54.Guohua Yang, Viviane N. Nenkep, Xavier N. Siwe, Alain S. Leutou, Zhile Feng, Dahai Zhang, Hong Dae Choi, Jung Sook Kang, and Byeng Wha Son. An acetophenone derivative, clavatol, and a benzodiazepine alkaloid, circumdatin A, from the marine-derived fungus Cladosporium.Natural Product Science, 2009, 15(3), 130-133.
55.张大海，李先国，孙炳华. 葡萄孢菌代谢产物α-吡喃酮酪氨酸酶抑制活性的研究. 中国海洋药物. 2008, 3, 35-38.
56.张大海，李先国，孙炳华. 天然产物葡萄孢酮立体构型的解析. 应用化学. 2008, 25(12), 1425-1429
57.冯丽娟，张大海，李先国. 一种多孔氧化镁晶须的制备.中国专利 CN, 200510044630.X.
